Complex nanoparticle design involves designing nanoscale structures (1-100nm) with complex architectures, multi-component integration, and customized functionalities to address advanced applications in science and industry. Unlike simple monolithic nanoparticles, complex designs combine hierarchical structures, heterogeneous components, or stimulus responsive elements to achieve synergistic performance beyond the capabilities of single component systems.
Synthesis and Design of Nanoparticles
The synthesis of nanoparticles is the foundation of nanomaterial design. We use a variety of advanced synthesis methods, including seed mediated method, DNA assisted assembly, self-assembly, sol-gel method, hydrothermal method, microfluidic technology, etc., to achieve accurate control of the size, shape and surface properties of nanoparticles. For example, gold nanoparticles (AuNPs) have attracted much attention due to their excellent stability, tunable optical properties, and wide applications in catalysis and biomedical fields. By adjusting the synthesis conditions, we can obtain nanoparticles of different shapes, such as spherical, rod-shaped, star shaped, tetrahedral, etc., to meet the needs of different application scenarios. In addition, the synthesis of magnetic nanoparticles, such as iron oxide nanoparticles, is also a key technology. We not only provide the classic co precipitation method, but also support reactions in confined environments to improve the purity and stability of nanoparticles. By introducing polymers or inorganic materials (such as silica and gold) as stabilizers, the aggregation and reunion of nanoparticles can be effectively prevented, thereby enhancing their potential applications in biomedical and magnetic resonance imaging (MRI) fields.
Figure 1. Synthesis and Design of Nanoparticles.
Our Services
Core Design Categories
| Core Design Categories | Descroption |
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| Core-Shell and Yolk-Shell Architectures | These structures consist of an inner core and an outer shell, often made of distinct materials, to decouple or synergize properties:- Core-Shell Nanoparticles: The shell protects the core (e.g., magnetic Fe₃O₄ core coated with biocompatible SiO₂ for biomedical imaging) or modulates surface interactions (e.g., gold core with polymer shell for controlled drug release).
- Yolk-Shell Nanoparticles: A hollow space between core and shell enables dynamic functions, such as pH-triggered release of cargo (e.g., doxorubicin-loaded yolk-shell nanoparticles responding to acidic tumor microenvironments).
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| Janus and Anisotropic Nanoparticles | Asymmetric structures with distinct chemical or physical properties on different surfaces:- Janus Nanoparticles: Bifunctional design (e.g., half gold/half iron oxide) enables simultaneous targeting and imaging, or catalytic activity and sensing.
- Anisotropic Nanostructures: Rods, plates, or stars with directional properties, such as gold nanorods with tunable plasmonic resonance for photothermal therapy and biosensing.
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| Porous and Hierarchical Nanoparticles | Structures with controlled porosity for enhanced surface area and cargo loading:- Mesoporous Nanoparticles: Uniform pores (2–50 nm) in silica or metal oxides for high drug loading (e.g., mesoporous silica nanoparticles carrying both chemotherapy and immunotherapy agents).
- Hierarchical Nanoparticles: Multi-scale porosity (micro- to nano-pores) for multi-modal applications, such as adsorbing pollutants of varying sizes in water treatment.
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| Bio-Conjugated Complex Nanoparticles | Integration of biological molecules (peptides, antibodies, nucleic acids) with nanomaterials for bio-specific functions:- Targeted Bio-Nanoparticles: Antibody-conjugated quantum dots for specific cancer cell labeling.
- Stimuli-Responsive Bio-Conjugates: Aptamer-functionalized nanoparticles that release drugs upon binding to tumor-specific biomarkers.
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Technical Components of the Service
Material Selection and Compatibility Engineering
- Multi-Material Integration: Expertise in combining metals, polymers, ceramics, and biomolecules while ensuring stability (e.g., preventing aggregation of lipid-polymer hybrid nanoparticles).
- Interface Engineering: Modulating core-shell or particle-biomolecule interfaces to enhance functionality (e.g., covalent linking of peptides to gold surfaces for improved targeting efficiency).
Advanced Fabrication Techniques
- Bottom-Up Synthesis: Controlled self-assembly (e.g., microemulsion methods for core-shell synthesis) and template-assisted growth (e.g., using porous alumina for nanorod fabrication).
- Top-Down Engineering: Precision etching (e.g., focused ion beam milling for Janus particle synthesis) and 3D nanolithography for custom architectures.
Characterization and Validation Tools
- Structural Analysis: High-resolution TEM (HRTEM) for core-shell interface imaging; X-ray diffraction (XRD) for crystal structure verification.
- Functional Testing: Dynamic light scattering (DLS) for size distribution; UV-Vis spectroscopy for plasmonic property validation; cell uptake assays for biomedical nanoparticles.
- In Silico Modeling: Molecular dynamics simulations to predict interactions (e.g., drug release kinetics from porous structures) and finite element analysis for mechanical property optimization.
Our Advantages
Customization
Tailored solutions for multi-functional needs (e.g., a single nanoparticle combining imaging, targeting, and therapy) that simple nanoparticles cannot address.
Expertise Integration
Access to interdisciplinary teams (materials scientists, biologists, engineers) ensuring seamless translation from design to application.
Scalability Support
Guidance on transitioning from lab-scale prototypes to industrial production, addressing challenges like batch consistency.
Workflow
Synthesis and Optimization
| Workflow | Descroption |
|---|
| Requirement analysis | Collaborative negotiation to determine functional objectives (e.g. "developing pH responsive, targeted drug delivery nanoparticles") and limitations (e.g. biocompatibility, expanding potential). |
| Conceptual design | Propose architecture and material combinations through computer simulation, and conduct feasibility assessment. |
| Prototype production | Use optimized parameters for small batch synthesis and iteratively adjust based on initial features. |
| Expand support | Optimize synthesis to achieve larger scale production (e.g. transition from laboratory scale to pilot production of porous catalyst nanoparticles). |
| Documentation and Compliance | Provide synthesis schemes, characterization data, and (for biomedical applications) regulatory compliance support. |
Summary
Complex nanoparticle design services are a key driving factor in harnessing the full potential of nanotechnology in addressing various challenges. The customized design of porous and bio conjugated structures provides tailored solutions for biomedical, energy, environmental, and sensing fields. By integrating advanced manufacturing, characterization, and modeling, they bridge the gap between conceptual innovation and practical applications. The workflow ensures that each project is validated at every stage, while the expertise of interdisciplinary teams minimizes risks and maximizes functionality. With the increasing demand for multifunctional nanoscale solutions in the industry, complex nanoparticle design services will play a key role in driving innovation and achieving breakthroughs that simple nanoparticles cannot achieve. For organizations seeking to harness the power of advanced nanomaterials, these services provide a strategic pathway for developing high-performance, application specific nanoparticles.
