Introduction
Magnetic beads have been widely used in various life science and biotechnology areas, such as molecular biology, immunology and diagnostic research. Magnetic beads have magnetic, functional surface and biochemical compatibilities and are widely used in the field of research and industry. The core of magnetic beads is to customize the properties to meet the application requirements. Our service presents the main characteristics of the custom magnetic beads, including surface chemistry and functional group customization, particle size and dispersion system optimization, magnetic property design and metal/fluorescent coating, hydrophilic/hydrophobic surface modification, internal structure customization, mechanical property customization, and surface charge customization.
Figure 1. Synthesis of peptide-immobilized magnetic bead.( Miyazaki, Hiroshi, et al.,2020)
Unrivaled Technical Expertise
In this era of dynamic biotechnology, diagnostics, and materials science, there is a growing demand for magnetic beads of highly specialized characteristics. Customized magnetic bead synthesis service is a key contributor to innovation. Highly specialized magnetic beads that can meet different demands and applications. We will use advanced technology and skilled scientists to produce magnetic beads that meet your expectations in terms of performance, functionality and reliability. Our facilities and equipment enable us to control every step of the synthesis of magnetic beads. From concept to the finished product, we can work with our customers to develop a product that meets their needs to produce the best results. Our products are suited for research, diagnostics and industrial uses.
Applications
Customized magnetic bead synthesis services can be applied to many industries and fields, such as:
Biotechnology and Pharmaceutical
Magnetic beads are commonly used in biotechnology and pharmaceutical fields such as protein purification, DNA extraction, cell separation and immunoassay. Our customized magnetic beads can be synthesized to satisfy the special needs of these fields with high sensitivity, specificity and reproducibility.
Diagnosis
Magnetic beads can be used for the detection and quantification of biomarkers, pathogens and other analytes in diagnosis. Our customized magnetic beads can be synthesized with the specific antibodies or nucleic acid probes to develop sensitive and specific detection methods.
Materials Science
Magnetic beads can be applied in materials science such as magnetic composite materials, sensors and actuators. Our customized magnetic beads can be synthesized to have specific magnetic property, surface chemical property and particle size.
Our Services
Our customized magnetic bead synthesis service covers a wide range of parameters, enabling us to manufacture magnetic beads that are fully suitable for your research or product development needs. We work closely with you to understand your project goals and translate them into precision designed magnetic bead solutions.
Magnetic Bead Surface Chemistry and Functional Group Customization
The surface of magnetic beads is its interface with the surrounding environment, playing a crucial role in its interaction with target molecules or cells. We offer a wide range of customized magnetic bead surface chemistry to ensure optimal binding, specificity, and stability.
- Amine (- NH2) functionalization
- Carboxyl functionalization (- COOH)
- Hydroxyl (- OH) functionalization
- Epoxy functionalization
- Protein A/G functionalization
- Thiol (-SH) functionalization
Magnetic Bead Size and Dispersion System Optimization
Size and Dispersion System Optimization
We can customize the particle size and dispersion system of magnetic beads. Our service can control the particle size of magnetic beads from a few nanometers to a few micrometers. We can also optimize the dispersion system to achieve a uniform particle size distribution and avoid aggregation, which can improve the reproducibility and reliability of our products. You can use the magnetic beads we provide to meet the needs of different applications, including monodisperse beads for high resolution separations or multi-dispersed beads for binding capacity enhancement. Our service include:
- Precise Size Control
- Tumor Microenvironment Models
- Nanometer-sized beads
- Optimized Dispersion Systems
- Aqueous suspensions
- Organic solvent dispersions
Magnetic Bead Magnetic Performance Design and Metal/Fluorescent Encapsulation
Magnetic beads are widely used in magnetic separation and detection. Our service provides customized magnetic performance design. We can control the magnetic saturation, coercivity and remanence of magnetic beads. We can coat the magnetic beads with metal materials such as gold, silver and nickel or fluorescent materials to improve their functions and detection. Surface modification of metal and fluorescent materials on magnetic beads has been used for many purposes, such as biosensing, imaging and targeted drug delivery.
Magnetic Bead Hydrophilic/Hydrophobic Surface Modification
The hydrophilicity of magnetic beads is important for the interaction with aqueous or organic phase and for avoiding nonspecific adsorption.
- Accurate hydrophilicity/hydrophobicity control: The hydrophilicity and hydrophobicity of magnetic beads can be accurately controlled from highly hydrophilic to highly hydrophobic or between them.
- Hydrophilic surface surface: Magnetic bead is coated with PEG, dextran, or charged polymers to create magnetic beads. The non-specific protein adsorption and dispersibility in aqueous solution are improved and the magnetic beads can be used for most biological applications.
- Hydrophobic surface: Magnetic bead can be made with alkyl chains or fluorinated compounds. It can be used for specific extraction, purification of hydrophobic molecules, or applications in non-aqueous environment.
Customization of Magnetic Bead Internal Structure
The internal structure of magnetic beads has a major influence on their magnetic properties, their stability and functionality. We can customize the internal structure of magnetic beads by adding different materials such as iron oxide, cobalt and nickel, or by making core-shell structures. The customizations of magnetic beads will have an effect on magnetic properties, stability and function according to the requirement of applications.
Customization of Magnetic Bead Mechanical Properties
In some applications, the mechanical properties of magnetic beads (e.g. strength, hardness, flexibility, etc.) may be an important factor. We can customize the mechanical properties of magnetic beads according to the requirement of different applications. We can change the composition, size and shape of magnetic beads so that they can meet the requirements of different processing and handling conditions.
Customization of Magnetic Bead Surface Charge
The surface charge of magnetic beads may affect their interactions with charged particles and biomolecules. We can customize the surface charge of magnetic beads from positive to negative. The customizations of surface charge will make the magnetic beads to have better binding affinity and specificity in different applications such as protein purification, cell separation and DNA extraction.
Our Advantages
When you choose to order your custom magnetic beads from us, you are working with the best scientific minds and customer support specialists.
Expertise and Experience
Our scientists, materials scientists and engineers have years of experience in nanoparticle synthesis and surface chemistry.
Advanced Technology
We use the latest synthesis, characterization and quality control equipment to ensure accurate and reliable service.
Collaboration Approach
From your initial inquiry to the delivery of your custom product, we will assist you with expertise and keep you informed of the synthesis process. Your needs drive our process.
Workflow
Synthesis and Optimization
Summary
The technology of custom magnetic bead synthesis allows for the creation of a new kind of magnetic bead that is specialized for a particular application. Customization of surface chemistry, particle size, magnetism, surface hydrophobicity/hydrophilicity, internal structure, mechanical properties and surface charge allows for the creation of magnetic beads for a variety of applications in molecular biology, immunology, diagnostics and biotechnology. With customized and functionalized magnetic beads, researchers and professionals can extend beyond biomedical and advanced diagnostics.
1. If my demand grows, can you increase the production of customized magnetic beads??
Of course, we considered scalability when designing the synthesis process. Once the customized bead formula is successfully developed and verified, we can work with you to expand the production scale to meet the larger quantity requirements of research and development and commercial.
2. What kind of QC is used for customized magnetic beads?
We will conduct QC based on your customized bead design. The common tests include DLS of size and PDI, VSM of magnetic properties, FTIR or XPS of surface chemical confirmation, zeta potential of surface charge, and the commonly used function test to confirm binding and binding ability, etc., related to your application. Each order has an analysis certificate.
3. Does customized magnetic beads have MOQ (minimum order quantity)?
Yes, for customized synthesis, MOQ is generally set for custom synthesis due to the resource consumption for a new synthesis. The MOQ of customized bead varies according to the customized weld bead and the specific parameters. If you can share your desired quantity with us during the initial discussion, we can adjust your proposal accordingly.
Reference
- Miyazaki, Hiroshi, et al. "Synthesis of peptide-immobilized magnetic beads, and peptide reactivity assay for assessing skin sensitization utilizing chromophore." Processes 8.10 (2020): 1257.
