CD Bioparticles offers a comprehensive magnetic size & distribution detection service, providing precise and multi-modal characterization of magnetic particle dimensions and population uniformity. Utilizing advanced analytical techniques, we deliver critical data on hydrodynamic diameter, polydispersity index (PDI), and morphological size distribution, ensuring your magnetic beads or nanoparticles meet stringent specifications for research, diagnostic, and therapeutic applications.
Introductions
The size and size distribution of magnetic particles are fundamental parameters that directly influence their performance in biological applications. Inconsistent size can lead to variable magnetic response, uneven surface area for conjugation, altered biodynamics, and ultimately, unreliable assay results or separation efficiency. CD Bioparticles addresses this critical need with our specialized detection service. We employ a combination of complementary techniques to provide a complete and accurate picture of your particle's physical dimensions, moving beyond a single average number to understand the full population distribution. This data is essential for quality control, process optimization, and ensuring batch-to-batch reproducibility.
Technology Overview
Our service integrates multiple, complementary analytical techniques to provide a complete size profile:
- Dynamic Light Scattering (DLS): This primary technique measures the hydrodynamic diameter of particles in suspension based on their Brownian motion. It provides:
- Z-Average Size: The intensity-weighted mean hydrodynamic diameter.
- Polydispersity Index (PDI): A dimensionless measure of the breadth of the size distribution (0-1 scale). A lower PDI indicates a more monodisperse population.
- Size Distribution by Intensity: A graph showing the relative population of different particle sizes.
- Laser Diffraction / Static Light Scattering: This method analyzes the angular variation in light scattering intensity from a laser beam passed through a dispersed sample. It is excellent for measuring a broader size range (from submicron to several microns) and provides a volume-based size distribution, which is less sensitive to the presence of a small number of aggregates or oversized particles compared to DLS.
- Electron Microscopy (SEM/TEM): For definitive, high-resolution morphological sizing and visualization.
- Scanning Electron Microscopy (SEM): Provides detailed topographical images to measure primary particle diameter, assess shape, and visually confirm monodispersity or identify aggregates.
- Transmission Electron Microscopy (TEM): Offers the highest resolution to measure core size, especially for nanoparticles, and analyze core-shell structures.
Our Services
We offer tiered and customized testing packages:
1. Basic Size Screening (DLS): Quick analysis of Z-average size and PDI in a standard buffer.
2. Comprehensive Size Profiling Package: A multi-technique approach combining DLS (for hydrodynamic size in application buffer), Laser Diffraction (for robust volume distribution), and SEM imaging (for verification of primary particle size and morphology).
3. Formulation Stability & Size Change Studies: Monitoring particle size over time or under different storage conditions (temperature, pH) to assess colloidal stability.
4. Aggregation & Contamination Analysis: Using DLS and microscopy to detect and quantify the presence of aggregates or oversized contaminants in a sample.
5. Detailed Reporting: Delivery of a professional report containing all raw data, distribution graphs, representative microscopy images, and clear interpretation of results against your specifications.
Applications
Accurate size data is vital for:
- Quality Control & Batch Release: Ensuring every production lot of magnetic beads falls within the specified size range and distribution limits.
- Research & Development: Optimizing synthesis and coating processes to achieve target particle size and improve monodispersity.
- Predicting In Vivo Behavior: Understanding how hydrodynamic size influences biodistribution, circulation time, and clearance for therapeutic particles.
- Troubleshooting Separation & Binding Issues: Correlating poor assay performance with undesirable particle aggregation or a shift in size distribution.
- Supporting Regulatory Documentation: Providing key physical characterization data for regulatory submissions of diagnostic or therapeutic products.
Our Process
Our approach is highly collaborative, ensuring the final product meets your exact specifications:
Synthesis and functionalization
Characterization and validation
Quality assurance and delivery
Our Advantages
Deep Technical Expertise
Over a decade of specialized experience in nanomaterial synthesis and advanced polymer chemistry, ensuring scientifically sound solutions. We work closely with clients as an extension of their R&D team.
Interdisciplinary Integration
We excel at bridging the gap between material science, nanotechnology, and biological application, ensuring our solutions are not only advanced but also practical and effective.
End-to-End Customization
We offer unparalleled flexibility, from providing raw materials to developing fully integrated, application-ready smart systems. Our processes are governed by strict quality control protocols.
In the world of magnetic particles, size truly matters. Consistent, well-defined size and distribution are prerequisites for predictable and high-performance applications. CD Bioparticles' Magnetic Size & Distribution Detection Service provides the precise, multi-faceted analytical data you need to control quality, guide development, and ensure your particles perform as designed. Contact CD Bioparticles to characterize the critical dimensions of your magnetic materials with confidence.
