Biofunctionalized Magnetic Bead Services

Introduction

CD Bioparticles  is a manufacturer and supplier of magnetic bead services. We have rich experience and technical platform, which can provide customers with comprehensive services from experimental design to result analysis. We not only provide high-quality magnetic bead products, but also offer customized magnetic bead surface functionalization and coupling services to meet the needs of different customers. We can provide solutions that meet the requirements for both academic research and industrial applications.

Magnetic beads, as a multifunctional and highly sensitive biomaterial, are widely used in various fields such as cell separation, protein purification, nucleic acid extraction, immunoassay, drug delivery, etc. CD Bioparticles , as an innovative manufacturer and supplier focused on the diagnostic field, is committed to providing customers with high-quality bio functionalized magnetic bead services. We not only provide standardized magnetic bead products, but also offer customized magnetic bead surface functionalization and coupling services to meet the needs of different customers.

Figure 1. Biofunctionalized Magnetic Bead Services. (Nguyen, Ngoc Van Thanh., et al. 2023)

Features of Biofunctionalized Magnetic Bead

Magnetic beads offer a versatile and flexible platform that can be used for many different applications and the following advantages:

• Efficient and Gentle Separation

  Magnetic separation is fast and does not require centrifugation or filtration.

• High Binding Capacity

  The large surface area of magnetic beads offers a large number of binding sites and ensures a high capture efficiency.

• Reproducibility and Scalability

  Protocols using magnetic beads have high reproducibility and scalability and can be used for small scale research or high-throughput applications.

• Automation Compatibility

  Biofunctionalized magnetic bead technology can be automated and can achieve high throughput and low hands-on time.

Applications

Customized magnetic bead synthesis services can be applied to many industries and fields, such as:

Our Services

CD Bioparticles  offers comprehensive services for the biofunctionalization of magnetic beads, including:

Protein/Antibody/Antigen Conjugation Services

We provide high-quality protein, antibody, and antigen conjugation services to meet the needs of different research and applications. These coupling services include：

• Standard lysine coupling
• Small-scale specific coupling
• Macromolecular crosslinking
• Large-scale specific coupling
• Covalent bead binding
• Custom ligand coupling

We use advanced chemical techniques for efficient and specific antibody conjugation, allowing for simple attachment of detection molecules near or far from the antigen binding domain, achieving covalent conjugation without altering antibody function.

Our services cover a variety of labeling chemistry, labeling options, quality control testing, minimum scale range, and estimated production. We specialize in enzyme/antibody conjugation and provide high-quality, affinity purified customized antibody labeling services aimed at meeting the needs of the research community. Each coupling is tailor-made for each customer, ensuring maximum utility and specificity to meet your needs.

Nucleic Acid Coupling Services

We provide labeling, modification, and conjugation services for nucleic acid probes, including DNA and RNA conjugation. These services can be used in research fields such as genomics, transcriptomics, proteomics, etc. We can also couple magnetic beads to protein and nucleic acid probes to achieve high-throughput biological analysis.

• Our nucleic acid conjugation services include various conjugation methods, such as covalent conjugation and non covalent conjugation.
• We use various coupling agents, such as maleic anhydride (HRP), alkaline phosphatase (AP), etc., to ensure the stability and specificity of the coupling

Fluorescence/Metal/Affinity Tag Coupling Service

We provide fluorescence labeling, metal labeling, and affinity tag coupling services to meet the needs of different research and applications. These services can be used for experiments such as immunofluorescence, immunoprecipitation, immunoblotting, etc. We can also couple fluorescent or metal labels onto magnetic beads to achieve high-sensitivity detection. We can also provide metal markers, such as gold markers, silver markers, etc.

• Fluorescence coupling service: Our fluorescence coupling service includes various fluorescent labels such as FITC, TRITC, Cy3, Cy5, etc.
• Affinity tags service: We can also provide affinity tags such as protein A, protein G, protein L, etc. to ensure the stability and specificity of the coupling.

Multi Functional Composite Coupling Service

We provide multifunctional composite coupling services to meet complex research needs. These services can couple various biomolecules onto magnetic beads for multi-target detection, multi-channel analysis, and more. We can also provide various coupling methods, such as covalent coupling, non covalent coupling, physical adsorption, etc. Our multifunctional composite coupling service includes multiple coupling methods, such as covalent coupling and non covalent coupling. We use various coupling agents, such as maleic anhydride (HRP), and alkaline phosphatase (AP).

Our Process for Surface Customization

Our approach is highly collaborative, ensuring the final product meets your exact specifications:

Our Advantages

Choosing our company for your custom magnetic bead surface chemistry means you benefit from:

Summary

With the continuous development of biomedical research, the application prospects of magnetic bead technology will be even broader.We will continue to offer high-quality bio functionalized magnetic beads to meet the diverse needs of customers. We believe that through continuous innovation and optimization, we can offer our customers more efficient, reliable and economical solutions. Whether you need a ready-to-use formula or a custom formula, CD Bioparticles can offer high-performance products with a quick turnaround.

FAQs

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1. What types of multifunctional composite coupling services can you provide?

We provide various types of multifunctional composite coupling services, including:

• Multi target coupling: coupling multiple target molecules (such as antibodies, antigens, fluorescent labels, metal labels) onto magnetic beads for multi-target detection.
• Multi channel coupling: coupling different types of labels (such as fluorescent, metallic, affinity tags) onto magnetic beads for multi-channel analysis.
• Covalent and non covalent binding: Provide a combination of covalent and non covalent coupling schemes according to experimental requirements.
• Physical adsorption combined with chemical coupling: In some cases, we can also use a combination of physical adsorption and chemical coupling to improve the stability and specificity of the coupling.

2. What types of fluorescence/metal/affinity tag coupling services can you provide?

We provide the following types of fluorescence, metal, and affinity tag coupling services:

• Fluorescence coupling: including FITC, TRITC, Cy3, Cy5, Alexa Fluor, etc., used for immunofluorescence, immunoblotting and other experiments.
• Metal coupling: including gold labeling, silver labeling, iron labeling, etc., used for immunological gold labeling, magnetic separation and other experiments.
• Affinity tag conjugation: including protein A, protein G, protein L, etc., used for immunoprecipitation, immunoblotting and other experiments.
• Multi functional coupling: It can simultaneously combine fluorescence, metal, and affinity tags for multi-channel detection, multi-target analysis, and other experiments.

3. What types of nucleic acid conjugation services can you provide?

We provide the following types of nucleic acid conjugation services:

• Coupling of DNA and RNA: used in genomics, transcriptomics, proteomics, and other research fields.
• Labeling of nucleic acid probes: used for experiments such as PCR, qPCR, microarrays, etc.
• Magnetic bead coupled nucleic acid probe: used for experiments such as magnetic bead extraction and separation.
• Multiple coupling methods: including covalent coupling and non covalent coupling, to ensure the stability and specificity of coupling.

Reference

1. Nguyen, Ngoc Van Thanh, et al. "Immuno-capture of biomolecules on functionalized magnetic beads: from characterization to fluorescent detection of a biomarker for Alzheimer's disease toward high performance biosensing." Talanta Open 8 (2023): 100264.