Multi-Omics Sample Pretreatment Magnetic Bead Labeling Service

CD Bioparticles introduces a cutting-edge multi-omics sample pretreatment magnetic bead labeling service, designed to streamline and enhance the critical initial phase of complex biological analysis. We provide integrated, custom solutions for the parallel or sequential isolation and preparation of multiple analyte classes—such as proteins, nucleic acids (DNA/RNA), metabolites, and lipids—from a single, precious biological sample. Our service leverages tailored magnetic bead-based labeling and capture strategies to deliver purified, analysis-ready fractions, significantly improving data quality, reproducibility, and integration for your genomics, proteomics, metabolomics, and lipidomics studies.

Introductions

The power of multi-omics research lies in generating layered, complementary datasets from a single sample source. However, this approach is often bottlenecked by disjointed, inefficient, and sample-intensive pretreatment protocols that can degrade analytes, introduce bias, and compromise data correlation. CD Bioparticles addresses this fundamental challenge. Our service provides a unified, bead-based pretreatment framework. We design and execute customized labeling and capture protocols that efficiently partition a single sample into high-purity fractions for different omics pipelines. This minimizes sample loss, reduces batch effects, and ensures that each downstream analytical platform receives an optimally prepared input, enabling more robust and biologically insightful multi-omics integration.

Technology Overview

Our service utilizes a modular platform of advanced bead chemistries and strategic protocol design:

• Analyte-Specific Capture Bead Libraries: We employ a curated toolkit of magnetic beads functionalized with diverse capture motifs: silica/charge-based for nucleic acid binding, hydrophobic/reverse-phase for lipids and metabolites, antibody/affinity-based for specific protein subsets, and mixed-mode beads for broad-protein or exosome capture.
• Sequential or Parallel Fractionation Design: We develop optimized workflows, such as:
  • Sequential Elution: Using beads with different binding affinities in a series to sequentially capture and release different analyte classes from the same lysate.
  • Condition-Specific Labeling: Modifying buffer conditions (pH, ionic strength, organic solvent) to direct specific analytes to corresponding bead types in a parallel or stepwise manner.
• On-Bead Tagging & Clean-up: For proteomics and metabolomics, we can integrate on-bead digestion, isotope labeling (e.g., TMT, SILAC), or chemical derivatization steps directly into the pretreatment process, reducing transfer losses and contamination.
• Cross-Contamination Minimization: Protocols are rigorously optimized with stringent wash steps and bead-specific elution conditions to ensure maximal purity of each isolated fraction for its intended omics analysis.

Our Services

We offer an end-to-end collaborative service, from protocol design to fraction delivery:

1. Workflow Consultation & Design: We analyze your sample type (cells, tissue, biofluids), target omics modalities (e.g., transcriptomics + proteomics), and sample volume constraints to propose an efficient, integrated pretreatment strategy.

2. Custom Protocol Development & Optimization: Our experts develop and optimize the multi-step bead-based labeling, binding, washing, and elution protocol tailored to your specific sample and analytical goals.

3. Service Execution:

• Sample Processing: You send us your raw samples, and we execute the full customized pretreatment workflow in our dedicated laboratories.
• Quality Control (QC): We perform QC on each generated fraction (e.g., bioanalyzer for nucleic acids, BCA/absorbance for protein, MS-ready check for metabolites).

4. Data & Delivery: You receive the purified, QC'd, and aliquoted fractions (e.g., RNA in nuclease-free buffer, peptides in MS-loading solution, metabolite extract) ready for immediate downstream analysis (NGS, LC-MS, etc.), along with a detailed process report.

Applications

This service is pivotal for advanced, integrative biomedical research:

• Integrated Cancer Biomarker Discovery: Simultaneous preparation of DNA (for mutations), RNA (for expression), and proteins (for pathways) from tumor biopsies or liquid biopsies to identify coordinated signatures.
• Host-Pathogen Interaction Studies: Fractionating infected cell samples to separately analyze pathogen nucleic acids and the host cell's transcriptional and proteomic response.
• Systems Biology & Mechanistic Studies: Obtaining perfectly matched genomic, proteomic, and metabolomic data from a single cell culture experiment or animal tissue sample to build comprehensive models.
• Clinical Cohort Profiling: Efficiently processing large sets of precious clinical samples (e.g., plasma, CSF) to generate multiple omics datasets with minimal technical variation.
• Exosome & Extracellular Vesicle Multi-Omics: Isolving vesicles and then sequentially extracting their RNA, protein, and lipid cargo for comprehensive characterization.

Our Process

Our approach is highly collaborative, ensuring the final product meets your exact specifications:

Our Advantages

Unlocking the true potential of multi-omics research requires rethinking sample preparation from an integrated perspective. CD Bioparticles' multi-omics sample pretreatment magnetic bead labeling service provides the specialized expertise and technological platform to transform complex, precious samples into a coherent set of high-quality inputs for your omics pipelines. Move beyond disconnected data generation towards truly unified biological insight. Contact CD Bioparticles to design an integrated pretreatment strategy for your next multi-omics project. Let us prepare the foundation for discovery.