Metal Concentration Analysis with ICP-MS

In the fields of environmental monitoring, pharmaceutical research, food safety, and material science, accurate detection of metal concentrations is crucial. Inductively Coupled Plasma Mass Spectrometry (ICP-MS) has become the preferred analytical technique in these fields due to its ultra-high sensitivity and wide applicability. At CD Bioparticles, we are committed to providing professional metal concentration analysis services based on ICP-MS, helping you accurately grasp the elemental composition and concentration information of samples.

Figure 1. Metal Concentration Analysis with ICP-MS.

Unrivaled Technical Expertise

Inductively Coupled Plasma Mass Spectrometry (ICP-MS) is an ultra sensitive analytical technique used to identify and quantify the elemental composition and/or concentration of a sample. Its core advantage lies in its ultra-high sensitivity, which can detect most metals and select non metals with sensitivity as low as ppt (parts per trillion) or ppq (parts per trillion) to detect certain elements. This sensitivity means that even trace amounts of metals in the sample can be accurately detected, which is of great significance for situations where trace metal elements may have a significant impact. In addition to ultra-high sensitivity, ICP-MS also has the advantage of a wide linear range. It can accurately quantify from trace amounts to high concentrations, avoiding the trouble of repeated sample dilution and greatly improving analysis efficiency. Meanwhile, this technology can achieve simultaneous analysis of multiple elements. While ensuring the accuracy of the results, it shortens the analysis time, making it particularly suitable for batch sample testing.

Our Services

Our ICP-MS metal concentration analysis services are designed to address the unique needs of each client, with a focus on versatility and precision.

Principles of ICP-MS Technology

The core principle of ICP-MS is to introduce the sample into a high-frequency electromagnetic field and ionize it through argon plasma. Subsequently, the ions are extracted into a mass spectrometer and separated and detected based on their mass to charge ratio (m/z). This technology has the following key features:

• High sensitivity: The detection limit of ICP-MS can reach ng/L, or even lower to pg/L, making it suitable for the analysis of trace elements.
• Simultaneous multi-element analysis: ICP-MS can simultaneously detect dozens of elements, including elements between lithium and uranium, making it suitable for the analysis of complex samples.
• High resolution: able to accurately distinguish isotopes, solve peak overlap problems, and improve analysis accuracy.
• Quick analysis: Full spectrum scanning can complete the measurement of most elements within 1-2 minutes.
• Low spectral interference: mainly composed of single charge ion peaks, simplifying data processing.
• Wide linear range: suitable for analysis from trace to high concentration, capable of measuring both major and trace components simultaneously.

Sample Preparation

The foundation of reliable ICP-MS analysis lies in proper sample preparation, and we offer a suite of techniques to handle any sample type:

• Microwave-Assisted Acid Digestion (CEM MARS 6): This technique is ideal for refractory samples (such as minerals, alloys, and ceramics) and biological materials (including tissues, blood, and cell cultures). The CEM MARS 6 system uses controlled microwave energy to create high-temperature, high-pressure conditions, breaking down even the most resistant matrices. For biological samples, this method minimizes the loss of volatile elements like mercury and arsenic while preventing contamination, ensuring complete dissolution of target elements.
• Matrix-Specific Processing: For simpler liquid samples (e.g., water, aqueous solutions), we use optimized dilution and filtration to remove particulates without altering elemental concentrations. Solid samples with high moisture content undergo controlled drying to eliminate interference, while organic samples (such as food products) are processed using solvent extraction or oxidation to reduce matrix effects.

Analytical Testing

Once samples are prepared, our state-of-the-art ICP-MS instruments perform quantitative analysis across a broad range of elements. We cover:

• Metals and Metalloids: From common elements like iron, copper, and zinc to toxic heavy metals such as lead, cadmium, and chromium.
• Trace and Ultra-Trace Analysis: Our instruments excel at detecting elements at ppt/ppq levels, critical for applications like environmental monitoring of pollutants or pharmaceutical impurity testing.
• Isotopic Analysis: For specialized research, we offer isotopic ratio measurements, supporting studies in geochemistry, forensics, and metabolic tracing.

Reporting and Support

After analysis, we deliver detailed reports including:

• Raw data and calibrated concentrations for each element.
• Method validation details, including detection limits and precision metrics.
• Interpretive summaries to help clients contextualize results (e.g., compliance with regulatory standards or implications for research outcomes). Our team of analysts is also available for follow-up consultations to address questions or refine methodologies.

Applications of ICP-MS in Various Industries

Our Advantages

Workflow

Summary

ICP-MS is a highly sensitive and accurate analytical technique widely used for metal concentration analysis. At CD Bioparticles, we provide comprehensive ICP-MS services, including sample pretreatment, instrument parameter optimization, analysis method selection, and data processing, to ensure the accuracy and reliability of analysis results. Whether you are engaged in environmental monitoring, biomedical research, or materials science, our ICP-MS service can provide you with high-quality analytical support. If you need further information about our services or have specific analytical needs, please feel free to contact us at any time.